Autoimmune Thrombocytopenic Purpura ("ITP" Type) with Chronic Lymphocytic Leukemia

Autoimmune thrombocytopenic purpura ("ITP" type) with chronic lymphocytic leukemia.

Update on chronic immune thrombocytopenic purpura (ITP)

Platelet production and circulation Thrombopoietin (TPO), the major cytokine affecting all phases of platelet production, is produced primarily by the liver and binds to the c-Mpl receptor located on platelets, stem cells and megakaryocytes. Upon stimulation, pluripotential stem cells produce cells committed to megakaryocyte differentiation. These cells initially undergo mitosis followed eventu...

About treatment of idiopathic thrombocytopenic purpura (ITP).

Their treatment results with megadose methylprednisolone (MDMP) support fairly closely our complete remission results, though theirs was a retrospective evaluation. In our prospective, comparative study, antiplatelet antibodies were also determined3. Their 80% complete remission rate (mistakenly written as 66% in the text) with MDMP administration was much better than other therapeutic approach...

Autoimmune thrombocytopenic purpura.

Adult autoimmune throbocytopenic purpura (ATP) is a platelet disorder that develops in certain individuals with a genetic as well as sex (female) predisposition following an environment event (?viral). This results in the production of an IgG antiplatelet antibody capable of reacting with the host's platelets, as well as crossing the placenta. This leads to the rapid clearance and destruction o...

Chronic autoimmune thrombocytopenic purpura associated with haemophilia A.

A 3 l-year-old white male was hospitalized in April 1980 with haemophilia A and autoimmune thrombocytopenic purpura. The diagnosis of haemophilia A (Factor VIII deficiency) had been made in infancy, when Factor VIII levels were found to be less than 5% of control. There was no family history of haemophilia. The patient had experienced numerous haemorrhagic complications, and was hospitalized on...